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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TOP2A
All Species:
47.88
Human Site:
Y590
Identified Species:
75.24
UniProt:
P11388
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P11388
NP_001058.2
1531
174385
Y590
N
K
Q
E
M
A
F
Y
S
L
P
E
F
E
E
Chimpanzee
Pan troglodytes
XP_516332
1634
184611
Y619
N
K
Q
E
L
S
F
Y
S
I
P
E
F
D
E
Rhesus Macaque
Macaca mulatta
XP_001092092
1620
182490
Y605
N
K
Q
E
L
S
F
Y
S
I
P
E
F
D
E
Dog
Lupus familis
XP_537646
1532
174610
Y590
N
K
Q
E
M
A
F
Y
S
L
P
E
F
E
E
Cat
Felis silvestris
Mouse
Mus musculus
Q01320
1528
172859
Y589
N
K
Q
E
I
A
F
Y
S
L
P
E
F
E
E
Rat
Rattus norvegicus
P41516
1526
173202
Y588
N
K
Q
E
I
A
F
Y
S
L
P
E
F
E
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001519680
1746
195650
Y618
N
K
Q
E
M
S
F
Y
S
L
P
E
F
E
E
Chicken
Gallus gallus
O42130
1553
174974
Y591
N
K
E
E
I
P
F
Y
S
I
P
E
F
E
E
Frog
Xenopus laevis
NP_001082502
1579
178601
Y588
N
K
Q
E
L
S
F
Y
S
I
P
E
F
E
E
Zebra Danio
Brachydanio rerio
NP_001003834
1574
177254
Y589
K
K
Q
E
I
S
F
Y
S
I
P
E
F
T
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P15348
1447
164377
Y570
K
N
E
E
L
S
F
Y
S
L
P
E
F
E
E
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q23670
1520
172316
Y625
G
K
E
E
V
S
F
Y
S
L
P
E
Y
S
E
Sea Urchin
Strong. purpuratus
XP_783546
1448
163750
F598
Q
R
N
F
L
E
E
F
I
T
P
I
V
K
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P30182
1473
164089
G582
I
V
K
A
T
R
K
G
T
K
K
V
L
S
F
Baker's Yeast
Sacchar. cerevisiae
P06786
1428
164196
K570
I
I
K
V
S
I
T
K
P
T
K
N
T
I
A
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
67.2
67.5
93.6
N.A.
89
88.7
N.A.
71.3
76.3
70.7
67.9
N.A.
51.2
N.A.
53
58.9
Protein Similarity:
100
78.6
78.4
96.4
N.A.
93.6
93.2
N.A.
79.1
85
81.8
78.8
N.A.
66.8
N.A.
70.4
73.4
P-Site Identity:
100
73.3
73.3
100
N.A.
93.3
93.3
N.A.
93.3
73.3
80
66.6
N.A.
66.6
N.A.
60
6.6
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
100
93.3
100
86.6
N.A.
86.6
N.A.
86.6
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
45
42.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
61.4
60.4
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
6.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
7
0
27
0
0
0
0
0
0
0
0
14
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
14
0
% D
% Glu:
0
0
20
80
0
7
7
0
0
0
0
80
0
54
80
% E
% Phe:
0
0
0
7
0
0
80
7
0
0
0
0
74
0
7
% F
% Gly:
7
0
0
0
0
0
0
7
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
14
7
0
0
27
7
0
0
7
34
0
7
0
7
0
% I
% Lys:
14
74
14
0
0
0
7
7
0
7
14
0
0
7
0
% K
% Leu:
0
0
0
0
34
0
0
0
0
47
0
0
7
0
0
% L
% Met:
0
0
0
0
20
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
60
7
7
0
0
0
0
0
0
0
0
7
0
0
0
% N
% Pro:
0
0
0
0
0
7
0
0
7
0
87
0
0
0
0
% P
% Gln:
7
0
60
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
7
0
0
0
7
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
7
47
0
0
80
0
0
0
0
14
0
% S
% Thr:
0
0
0
0
7
0
7
0
7
14
0
0
7
7
0
% T
% Val:
0
7
0
7
7
0
0
0
0
0
0
7
7
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
80
0
0
0
0
7
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _